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对６４例原发性肺癌、３２例肺良性疾病患者和３２名健康人外周血癌胚抗原、总唾液酸、脂质结合唾液酸检测的结果表明：肺癌患者血清癌胚抗原、总唾液酸以及脂质结合唾液酸含量显著高于肺良性疾病者和健康人。三项指标对肺癌诊断的敏感性分别为５４．６８％、８７．６０％、７０．１３％；诊断特异性分别为９５．３１％、８５．９４％、９５．３１％。联合检测总唾液酸与癌胚抗原能提高对肺癌诊断的敏感性及特异性。提示检测癌胚抗原等三种标记物对肺癌的诊断、鉴别诊断有较高的临床实用价值。
The results of detection of peripheral carcinoembryonic antigen, total sialic acid, and lipid-associated sialic acid in 64 patients with primary lung cancer, 32 patients with benign lung disease, and 32 healthy individuals showed that serum carcinoembryonic antigen, total sialic acid, and lipids in patients with lung cancer The content of sialic acid in the combined plasm is significantly higher than that in the benign lung disease and healthy people. The sensitivity of the three indicators to the diagnosis of lung cancer was 54.68%, 87.60%, and 70.13%, respectively; the diagnostic specificity was 95.31%, 85.94%, and 95.31%, respectively. Combined detection of total sialic acid and carcinoembryonic antigen can improve the sensitivity and specificity of lung cancer diagnosis. This suggests that the detection of three markers such as carcinoembryonic antigen has a high clinical value in the diagnosis and differential diagnosis of lung cancer.