心肌重构与多种心血管疾病的发生、发展密切相关,是一种复杂的病理过程,其发病机制迄今尚未完全阐明。基质金属蛋白酶家族是其中一个重要的影响因素,其表达主要受一系列神经内分泌因素、细胞因子、活性氧等因素的影响。现就心肌重构过程中影响基质金属蛋白酶表达的因素及其可能的分子生物学机制予以综述。 Cardiac remodeling is closely related to the occurrence and development of a variety of cardiovascular diseases. It is a complex pathological process, and its pathogenesis has not yet been fully elucidated. Matrix metalloproteinases (MMPs) are one of the most important influencing factors. Their expression is mainly affected by a series of neuroendocrine factors, cytokines and reactive oxygen species. Now on myocardial remodeling affect the expression of matrix metalloproteinase and its possible molecular mechanism of molecular biology are reviewed.