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血管性痴呆(VAD)已成为临床常见的疾患之一。约20～40％的脑血管病患者伴有程度不同的智能障碍。既往认为,痴呆的发生为脑动脉硬化的结果。Hachinski(1974)经病理研究指出,多发性的双侧半球缺血卒中是导致认识障碍的直接原因,提出“多梗塞性痴呆”(MID)的诊断,并作为一个特殊的临床疾病实体。进一步的研究表明,除MID外,还存在与血管因素有关,而以其它不同形式表现的痴呆者。轻微的卒中,损害了脑重要部位或单一的大片梗塞及皮质下白质的变化,均可导致痴呆而并非决定于脑多梗塞的存
Vascular dementia (VAD) has become one of the common clinical diseases. About 20 ~ 40% of patients with cerebrovascular disease with varying degrees of mental retardation. In the past that the incidence of dementia as a result of cerebral arteriosclerosis. Hachinski (1974) pointed out that pathological studies have shown that multiple hemispheric ischemic stroke is the direct cause of cognitive impairment and proposed the diagnosis of “multi-infarct dementia” (MID) as a specific clinical disease entity. Further studies have shown that, in addition to MID, there are also related to vascular factors, while in different forms of dementia. Slight stroke, damage to important parts of the brain or a single large infarct and subcortical white matter changes, can lead to dementia and not determined by the presence of cerebral infarction