间三氟甲基苯乙酮(3-Trifluoromethylacetophenone)简称TFAP,淡黄色液体,主要用于医药、农药和染料等领域。它是合成甲氧基丙烯酸酯类化合物肟菌酯(Trifloxystrobin,商品名Flint)的关键中间体,同时也是合成医药、染料的重要原料。国内外报道的合成间三氟甲基苯乙酮的方法有:间三氟甲基苯甲氰与碘甲烷的格氏反应后再水解;间三氟甲基苯甲酸经酰氯化后和碘甲烷的镉试剂反应;间三氟甲基苯甲醛和重氮甲烷反应;间三氟甲基溴苯的格氏 3-Trifluoromethylacetophenone, abbreviated as TFAP, is a light yellow liquid mainly used in the fields of medicine, pesticide and dye. It is a key intermediate in the synthesis of trimethoxydate (Trifloxystrobin, trade name Flint) and is also an important raw material for the synthesis of pharmaceuticals and dyes. At home and abroad reported the synthesis of m-trifluoromethyl acetophenone methods are: m-trifluoromethyl benzene methyl cyanide and methyl iodide Grignard reaction and then hydrolysis; m-trifluoromethyl benzoic acid chloride and methyl iodide Of the cadmium reagent; m-trifluoromethyl benzaldehyde and diazomethane; m-trifluoromethyl bromobenzene Grignard