牛磺酸和取代牛磺酸既是一类重要的天然氨基酸,也是天然蛋白氨基酸的含硫类似物,具有重要的生理活性。结合作者课题组的研究工作介绍了近年来取代牛磺酸的合成研究进展,特别是作者课题组发展的多种无盐合成法,可以方便地合成高纯度的取代牛磺酸,包括1-和2-单取代牛磺酸,1,1-,1,2-和2,2-二取代牛磺酸。 Taurine and substituted taurine are both important natural amino acids and sulfur-containing analogues of natural protein amino acids, which have important physiological activities. In combination with the research work of the author’s group, the recent progress in the synthesis of taurine instead of taurine is introduced. In particular, the salt-free synthesis method developed by the research group of the authors facilitates the synthesis of high-purity substituted taurine, including 1- and 2-monosubstituted taurine, 1,1-, 1,2- and 2,2-disubstituted taurine.