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目的探讨miRNA-206在胃间质瘤中的表达及意义。方法收集胃间质瘤治疗后的切除标本,采用qRT-PCR方法检测53例胃间质瘤及对应正常胃组织中miRNA-206的表达,并分析其与临床病理因素的关系。结果胃间质瘤组织中miRNA-206表达显著低于对应正常胃组织(P<0.05),且核分裂数≥5/50 HPF病例的miRNA-206表达显著低于核分裂数<5/50 HPF病例的miRNA-206表达(P<0.05),Fletcher分级中/高危病例的miRNA-206表达显著低于极低/低危分级病例的miRNA-206表达(P<0.05)。结论 miRNA-206在胃间质瘤组织中表达下调,且与核分裂像及Fletcher分级密切相关,提示其在胃间质瘤的发生发展过程中发挥重要作用。
Objective To investigate the expression and significance of miRNA-206 in gastric stromal tumors. Methods The specimens of gastric stromal tumors were collected and the expression of miRNA-206 in 53 cases of gastric stromal tumors and corresponding normal gastric tissues was detected by qRT-PCR. The relationship between miRNA-206 and clinical pathological factors was analyzed. Results The expression of miRNA-206 in gastric stromal tumors was significantly lower than that in normal gastric tissues (P <0.05), and the miRNA-206 expression was significantly lower in cases with mitotic frequency ≥5 / 50 HPF than that in cases with mitotic frequency <5/50 HPF (P <0.05). The miRNA-206 expression was significantly lower in Fletcher-graded mid-high-risk cases than that in ultra-low / low-risk cases (P <0.05). Conclusions The expression of miRNA-206 is down-regulated in gastric stromal tumors and closely related to mitotic figures and Fletcher grades, suggesting that miRNA-206 plays an important role in the development and progression of gastric stromal tumors.