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目的探讨中国汉族人群非家族性房颤和血管紧张素原(AGT)基因多态性之间的关系。方法纳入701例非家族性房颤(房颤组)和763例健康人群(对照组),应用基因位点分析和单倍型分析研究AGT基因的7个标签单核苷酸多态性(SNP,rs7539020,rs3789678,rs2478544,rs11568023,rs2478523,rs4762,rs699)与非家族性房颤的相关性。结果位点分析显示,房颤组rs2478523-CC和rs11568023-TT基因型出现的频率明显高于对照组,差异具有统计学意义(P<0.05),rs2478523和rs11568023无连锁不平衡关系,基因单倍型分析未发现与房颤相关的单倍型基因。结论 AGT基因的rs2478523和rs11568023和中国汉族人群中的非家族性房颤相关。
Objective To investigate the relationship between non-familial atrial fibrillation and angiotensinogen (AGT) gene polymorphisms in Chinese Han population. METHODS: A total of 701 non-familial atrial fibrillation (AF) patients and 763 healthy subjects (control group) were enrolled in this study. Seven SNPs of the AGT gene were analyzed by gene locus analysis and haplotype analysis , rs7539020, rs3789678, rs2478544, rs11568023, rs2478523, rs4762, rs699) and non-familial atrial fibrillation. The results of site analysis showed that the frequencies of rs2478523-CC and rs11568023-TT genotypes in AF group were significantly higher than those in control group (P <0.05), rs2478523 and rs11568023 had no linkage disequilibrium, Type analysis found no haplotype associated with atrial fibrillation. Conclusion The AGT gene rs2478523 and rs11568023 are associated with non-familial AF in Chinese Han population.