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牛心朴子对线虫的杀线活性的研究证实,牛心朴子甲醇提取物对松材线虫的杀线活性随时间和提取物浓度增加明显增加;紫外线和加热处理会使其提取物失活,提取物的新鲜度会影响其活性。分析认为牛心朴子的毒性机理是干扰线虫葡萄糖和蛋白质代谢,抑制SOD活性,诱导POD和CAT活性,进而产生自由基摧毁保护酶系统,同时抑制AChE活性,破坏神经系统,抑制GST活性,并干扰解毒酶系统的代谢。四合木的毒性机理是干扰线虫葡萄糖和蛋白质代谢,抑制SOD活性,诱导POD和CAT活性,进而产生自由基或改变酶分子,这样就会导致损毁保护酶系统,对AChE和AKP的作用类似牛心朴子的情况。鄂尔多斯半日花的毒性机理是干扰线虫葡萄糖和蛋白质代谢,抑制SOD活性,诱导POD和CAT活性,进而产生自由基摧毁保护酶系统,同时抑制AChE活性,破坏神经系统。
The inhibitory activity of bovine Xipuzi against nematodes confirmed that the killing activity of methanol extract of M. przewalskii to Bursaphelenchus xylophilus increased significantly with the increase of time and concentration of extracts; UV and heat treatment could inactivate its extract, Freshness can affect its activity. It is concluded that the toxicity mechanism of M. przewalskii is to interfere with the glucose and protein metabolism of C. elegans, inhibit the activity of SOD and induce the activity of POD and CAT, then generate free radicals to destroy the protective enzyme system, inhibit AChE activity, destroy the nervous system, inhibit GST activity and interfere with detoxification The metabolism of the enzyme system. Tetraena toxic mechanism is to interfere with nematode glucose and protein metabolism, inhibit SOD activity, induce POD and CAT activity, and then produce free radicals or enzyme molecules, which will lead to damage the protective enzyme system, the role of AChE and AKP Child’s situation. The toxicity mechanism of Erdos half-day flower is to disturb the metabolism of glucose and protein in nematodes, inhibit the activity of SOD, induce the activities of POD and CAT, and then generate free radicals to destroy the protective enzyme system, inhibit AChE activity and destroy the nervous system.