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急性变常发生于慢粒的终末期,偶有个别患者初诊时即表现急性变,这些患者Ph~1染色体阳性,其临床症状和细胞形态与急粒白血病无法区别。认别这些罕见类型的慢粒有助于更好认识慢粒的自然过程,以及选择更有效的治疗方法。
Acute exacerbation occurs in the terminal phase of CML, with occasional individual patients presenting acutely when initially diagnosed. Ph ~ 1 chromosomes are positive in these patients and their clinical symptoms and cell morphology are indistinguishable from acute myeloid leukemia. Identifying these rare types of slow granules helps to better understand the natural processes of slow granules and to choose more effective treatments.