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目的了解江西省南昌市新生儿和母亲配对麻疹抗体水平及0～8月龄婴幼儿麻疹抗体水平变化情况。方法应用酶联免疫吸附试验(ELISA)法对婴幼儿及其母亲进行麻疹抗体IgG水平测定,几何抗体平均滴度(GMT)≥1∶200为阳性,GMT≥1∶800为有保护性。结果新生儿脐血与母血抗体GMT分别为1∶408、1∶483,GMT接近一致,母亲抗体阳性率为85.71%,婴儿抗体阳性率为77.14%,差异无统计学意义(χ2=1.70,P>0.05)。随时间推移,母传抗体GMT随月龄增大而逐渐下降,GMT由新生儿的1∶408降至8月龄的1∶112,GMT多未达保护水平。6～8月龄婴儿抗体水平下降明显,保护性抗体水平降至30%以下。结论建议对育龄妇女进行麻疹疫苗接种,提高婴儿麻疹疫苗首针及时率,降低麻疹发病率,以尽快达到消除麻疹的目的。
Objective To understand the level of mate antibody against measles in neonates and mothers and the level of measles antibody in infants aged 0-8 months in Nanchang, Jiangxi Province. Methods The IgG level of measles antibody was detected by enzyme-linked immunosorbent assay (ELISA). The geometric mean antibody titer (GMT) ≥1: 200 was positive and the GMT≥1: 800 was protective. Results The neonatal umbilical cord blood and maternal serum antibody GMT were 1:408,1:483, GMT close to the same, the mother antibody positive rate was 85.71%, the infant antibody positive rate was 77.14%, the difference was not statistically significant (χ2 = 1.70, P> 0.05). Over time, the mother-of-body antibody GMT gradually decreased with increasing age, GMT dropped from 1:408 neonatal to 8-month-old 1: 112, GMT has not reached the level of protection. The levels of antibodies in 6-8 month-old infants decreased significantly, and the levels of protective antibodies decreased below 30%. Conclusion It is suggested that measles vaccine should be given to women of childbearing age to improve the first-in-time rate of measles vaccine and reduce the incidence of measles so as to eliminate the measles quickly.