论文部分内容阅读
利多卡因作为一种安全有效的局麻用药,近年来广泛应用于纤支镜检(FFB),以及支气管-肺泡灌洗(BAL)术前的气道麻醉。支气管—肺泡灌洗液(BALF)的各种生化、免疫及细胞学检测为临床各种疾病的诊断治疗提供了有力的证据。但是含有利多卡因的BALF中,各种免疫活性细胞的功能是否受到影响,能否使BALF各项化验产生误差,都有待明确。本文对13例病人双侧对应正常肺段的灌洗液进行对比发现:1.不同浓度的利多卡因对BALF多种细胞的结构和功能产生不同的影响。2.在对BALF细胞存活率的比较中,以含2％利多卡因的BALF中细胞存活率最低。3.反映细胞活性的巨噬细胞发光试验中,利多卡因达2％浓度时细胞发光能力明显下降。4.含利多卡因的BALF中细胞总数明显增加,尤以2％浓度时更为明显,但其浓度含量对细胞成份不产生影响。因此,应当选择合适的利多卡因浓度进行BAL,如果在FFB过程中麻醉效果满意,则可在BAL前不再追加利多卡因。
Lidocaine, as a safe and effective local anesthetic, has been widely used in bronchoscopy (FFB) and airway anesthesia before bronchoalveolar lavage (BAL) in recent years. Various biochemical, immunological and cytological tests of bronchoalveolar lavage fluid (BALF) provide strong evidence for the diagnosis and treatment of various clinical diseases. However, with the lidocaine-containing BALF, whether the function of various immunocompetent cells is affected or not, it is yet to be clarified whether BALP assays can be error-prone. In this paper, 13 cases of bilateral corresponding normal lung segment of the lavage fluid were compared: 1. Different concentrations of lidocaine BAL cells in a variety of cell structure and function of different effects. In the comparison of BALF cell viability, the cell survival rate in BALF containing 2% lidocaine was the lowest. 3. Reflect the cell activity of macrophages in luminescence test, lidocaine 2% concentration of cells decreased significantly when the light-emitting capacity. The total number of cells in the BALF containing lidocaine significantly increased, especially at 2% concentration, but the concentration of the composition did not affect the cell composition. Therefore, a suitable concentration of lidocaine should be chosen for BAL. No lidocaine may be added before the BAL if anesthesia is satisfactory during FFB.