乳头乳晕角化过度症是一种罕见皮肤病,国内文献仅报告过2次。现将我所见1例报告如下。 患者,女性,19岁,未婚。因双侧乳头乳晕变黑,长硬痂5年而就诊。5年前,患者无明显诱因,先左侧后右侧的乳头乳晕色素沉着加深。继之长出黑褐色痂皮,逐渐增厚,且皮损缓慢扩大,无任何感觉,无 Nipple hyperkeratosis is a rare skin disease that has only been reported twice in domestic literature. Now I see a case report as follows. Patient, female, 19 years old, unmarried. Due to dark nipples, the areola became dark and the hard palate was seen for 5 years. Five years ago, there was no obvious cause for the patient. The left and right posterior right nipple isola was deepened. Following the growth of dark brown tanned skin, it gradually thickens, and the skin lesions slowly expand without any feeling.