Dear editor,rnWe thank Lopes et al.1 for their interest in our study and for writing an insightful commentary based on our findings, which were recently published in the Journal of Sport and Health Science,2 and for their work.3 As noted by the authors, there is consistency in several key findings between our laboratories, and this should serve as a basis for future investigation in this area. We agree that there has been little work examining the effect of high-intensity interval exercise (HIIE) on central arterial stiffness, wave reflections, and hemodynamic responses. However, research is particularly lacking in adults with metabolic diseases, a population with a significantly increased risk of developing cardiovascular disease and cardiovascular mortality. To further the impor-tant discussion Lopes et al.1 have raised in their commen-tary, our response focuses on raising additional points concerning the responses in central arterial stiffness, wave reflections, and hemodynamics observed following HIIE in adults with metabolic diseases. With this, we hope to shed light on the importance of research in HIIE for this popula-tion and their arterial health.