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目的 :研究探讨血清芳香酯酶 ( Ar E)活性在慢性肾衰竭 ( CRF)时的变化规律及其临床意义。方法 :通过测定 5 7例 CRF患者血清 Ar E活性及血脂、脂蛋白、载脂蛋白的浓度 ,然后将患者组和健康对照组进行统计处理 ,对比分析。结果 :CRF患者血清 Ar E活性 ( 0 .2 0 0± 0 .0 4 2 ) U/ ml,Ar E/ TC( 0 .0 4 4± 0 .0 0 3 ) ,Ar E/ HDL- C( 0 .18± 0 .0 4 ) ,Ar E/ HDL3- C( 0 .3 92± 0 .12 0 )水平显著低于对照组。其变化规律与 HDL - C、HDL2 - C、HDL - C/ TC、HDL2 - C/ HDL3- C、Apo- A1 / Apo- B1 0 0 相似 ,且 Ar E的水平与 HDL - C、HDL2 - C、Apo- A1 呈正相关 ,相关系数 r分别为 0 .3 7、0 .5 1和 0 .2 9、Ar E/ TC与 HDL - C/ TC、HDL2 - C/ TC、Apo- A1 / Apo- B1 0 0 的相关系数依次为 0 .60、0 .67、0 .5 7,为正相关关系。血清 Ar E和清蛋白呈正相关 ( r=0 .5 4 3 )而与肌酐呈负相关 ( r=- 0 .3 5 9)。Ar E活性降低先于 TC、HDL - C和 Apo- A1 水平的改变。结论 :血清 Ar E活性是反映 CRF患者并发脂代谢紊乱的较好指标 ,并能提示肾衰竭的严重程度。
Objective: To investigate the changes of serum aromatase (Ar E) activity in chronic renal failure (CRF) and its clinical significance. Methods: Serum Ar E activity and serum lipoprotein, lipoprotein and apolipoprotein concentrations in 57 patients with CRF were measured, and then the patients and healthy controls were statistically analyzed and compared. Results: The serum Ar E activity (0.220 ± 0.042) U / ml, Ar E / TC (0.044 ± 0.303) and Ar E / HDL-C 0 .18 ± 0. 0 4), Ar E / HDL3-C (0.3292 ± 0.12 0) levels were significantly lower than the control group. The change law was similar to HDL - C, HDL2 - C, HDL - C / TC, HDL2 - C / HDL3 - C and Apo - A1 / Apo - B1 0 0. , Apo-A1, Apo-A1, Apo-A1 and Apo-A1, the correlation coefficients r were 0.33, 0.50 and 0.29, The correlation coefficient of B1 0 0 is 0 .60,0 .67,0. 57, which is a positive correlation. Serum Ar E was positively correlated with albumin (r = 0.545) and negatively correlated with creatinine (r = -0.359). Ar E activity decreased prior to TC, HDL - C and Apo-A1 levels. Conclusion: Serum Ar E activity is a good indicator to reflect the disorder of lipid metabolism in patients with CRF and can prompt the severity of renal failure.