论文部分内容阅读
抗肿瘤药物能通过中断细胞分裂与杀死进行性生长细胞而抑制肿瘤生长。用这些制剂治疗病人可能产生某种有害作用,包括造血影响,发生“第二次恶性变”,损害生殖功能,免疫抑制,以及有报道,受治疗的母亲生育畸形婴儿。有关报道以及此类药物诱变作用的实验室证据,引起人们注意这些药物可能对处理药物的医务人员产生危害作用。为了评估这种危险,Falck等人在1979年利用沙门氏菌属回复试验证明处理细胞抑制药物的护士的尿有诱变性。通过这种试验测定,证明了尿的诱变性在工作日期间增强,在周末间歇期因无接触而减弱。Waksvik等人在1981年发现处理细胞抑制药物的护士的染色体脱节与断裂有剂量依赖性加强。他们也发现与前述报导一样,诱变性在工作日期间增强,在周末休息日减弱。如果在调制这类药物时应用经推荐的安全程序或生物安全柜,则尿诱变性减弱或消失。
Antineoplastic agents can inhibit tumor growth by disrupting cell division and killing the cells that progressively grow. Treating patients with these preparations may have some detrimental effects, including hematopoietic effects, “second malignancy”, impaired reproductive function, immunosuppression, and reported maternal malformed babies. Laboratory evidence of reports and the mutagenicity of such drugs has drawn the attention that these drugs may have a detrimental effect on the medical staff who handle the drugs. In order to assess this risk, Falck et al. Used Salmonella back-up tests in 1979 to demonstrate the urine mutagenicity of nurses handling cytostatic drugs. By this test assay, it was demonstrated that urine mutagenicity increased during the working day and weakened during the weekends due to no contact. In 1981, Waksvik et al. Found that nude patients treated with cytostatics had a dose-dependent enhancement of chromosome segregation and fragmentation. They also found that, like the previous reports, mutagenicity increased during weekdays and weakened on weekends. Urine mutagenicity diminishes or disappears if the recommended safety procedures or biological safety cabinets are used when modulating such drugs.