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我所与中国科学院微生物研究所,江苏无锡酶制剂厂、江苏射阳制药厂等单位协作,试制成AS1.398药用中性蛋白酶肠溶衣片(以下简称中性蛋白酶),于1977年1月～1979年3月,先后在本省淮北、江南两地,以脱盐的和丙酮提纯的中性蛋白酶,设单味、复方、空白对照和服安慰剂(淀粉糖衣片)组,进行临床验证,现将临床验证情况及其疗效总结如下: 一、病例选择按1972年全国《慢性气管炎临床诊断及疗效判断标准》,中医分型按1974年11月份《全国部分省市防治慢性气管炎临床座谈会》制定的标准,先由基层医务人员将所在地区慢性支
I worked with Institute of Microbiology, Chinese Academy of Sciences, Jiangsu Wuxi enzyme preparation plant, Jiangsu Sheyang Pharmaceutical Factory and other units, trial production AS1.398 pharmaceutical neutral protease enteric-coated tablets (hereinafter referred to as neutral protease), in 1977 From January to March 1979, clinical trials were performed in the Huaibei and Jiangnan areas of the province with neutral protease purified with desalted and acetone followed by single-flavor, compound and blank control and placebo tablets (starch and sugar-coated tablets) Now the clinical verification of the situation and its efficacy are summarized as follows: First, the case selection According to the 1972 national “chronic bronchitis clinical diagnosis and efficacy of judgment criteria”, TCM classification by November 1974 “part of the provinces and cities in the prevention and treatment of chronic bronchitis clinical discussion Will ”set the standard, first by the grass-roots medical staff will be chronic regional branch