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目的：观察ｂｃｌ２ 基因表达对涎腺癌发生及发展的关系。方法：采用免疫组织化学法对５５ 例涎腺癌、２５ 例癌旁涎腺组织及１１ 例多形性腺瘤组织ｂｃｌ２ 表达产物进行检测。结果：涎腺癌组织ｂｃｌ２ 阳性表达明显高于癌旁涎腺组织及多形性腺瘤。ｂｃｌ２ 表达与涎腺癌的临床分期及恶性程度有关，临床晚期组（Ⅲ～Ⅳ期）及恶性程度较高组ｂｃｌ２ 呈现高表达。结论：ｂｃｌ２ 在涎腺癌中的高表达可能参与了涎腺癌的发生及发展过程。
Objective: To observe the relationship between the expression of bcl 2 gene and the development of salivary gland carcinoma. Methods: Immunohistochemistry was used to detect the expression of bcl2 in 55 cases of salivary gland carcinoma, 25 cases of para-cancerous salivary gland tissues and 11 cases of pleomorphic adenoma tissues. Results: The expression of bcl2 in salivary gland cancer tissues was significantly higher than that in paracancer salivary gland tissues and pleomorphic adenomas. bcl 2 expression and salivary gland cancer clinical stage and degree of malignancy, clinical late stage (Ⅲ ~ Ⅳ) and higher malignant bcl 2 showed high expression. Conclusion: The high expression of bcl2 in salivary gland carcinoma may be involved in the occurrence and development of salivary gland carcinoma.