患者女,16岁。2岁时因右颌下无痛性硬块在我院行手术切除,病理报告为骨嗜酸性肉芽肿,术后未再复发。8岁时出现明显多饮、多尿,伴消瘦、乏力,在当地医院诊为尿崩症,采用中西药物治疗,症状有所减轻。2年前春季开始不明原因发热(37～38℃),伴头痛、咽干、腰部及髋部疼痛,两侧季肋部皮肤出现3个花生米大的小结节,质韧、无红肿、疼痛及瘙痒,自行破溃后有黄色分泌 Female patient, 16 years old. 2 years old due to the right mandibular painless lump in our hospital underwent surgical excision, the pathological report of eosinophilic granuloma, no recurrence after surgery. 8 years old when there was obvious polydipsia, polyuria, with weight loss, fatigue, diagnosed as diabetes insipidus in the local hospital, the use of Chinese and Western medicine, the symptoms have eased. Two years ago, the onset of unexplained fever (37-38 ° C) in the spring with headache, throat dryness, pain in the waist and hips resulted in the appearance of three small peanut nodules on the skin on both sides of the ribs. Pain and itching, self-ulceration after yellow secretion