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探讨人宫颈癌中c-erbB-2基因表达的改变及其临床意义 方法 对123例宫颈癌和26例非癌的宫颈组织采用免疫组化ABC法检测c-erbB-2基因蛋白的表达,结合临床资料分析该基因改变的临床意义。结果 正常宫颈组织中未见阳性染色,16例慢性宫颈炎中有3例阳性。强度为(阳性),宫颈癌组织中c-erbB-2基因表达为31.14％(42/123),显著高于正常和有慢性炎症的宫颈组织(P<0.01),并显示其与宫颈癌病理组织学分化高低及存活期有关。结论 c-erbB-2基因的变化在宫颈癌的发生和发展中起重要作用,其过度表达提示较差的临床行为和预后。
To investigate the alteration of c-erbB-2 gene expression in human cervical cancer and its clinical significance Methods 123 cases of cervical cancer and 26 cases of non-cancerous cervical tissue were examined for the expression of c-erbB-2 gene by immunohistochemical ABC method. Clinical data analysis of the clinical significance of gene changes. Results No normal cervical tissue staining, 16 cases of chronic cervicitis in 3 cases were positive. The positive expression rate of c-erbB-2 in cervical cancer was 31.14% (42/123), which was significantly higher than that in normal and chronic cervix tissues (P <0.01) Histological differentiation and survival of the relevant. Conclusion The change of c-erbB-2 gene plays an important role in the occurrence and development of cervical cancer. The over-expression of c-erbB-2 gene implies poor clinical behavior and prognosis.