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Objective: To clarify the effect of intraarterial chemotherapy on vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) count in carcinoma of the cervix. Methods: Before intraarterial chemotherapy and after2-3 weeks of therapy, the expression of VEGF and MVD count in 36 carcinoma tissues of locally advanced cervical cancer were determined by CD34. Results: Before intraarterial chemotherapy and after 2-3 weeks, the expression of VEGF were75% (27/36) and 30.6% (11/36) respectively, and MVD were reduced obviously (P＜0.001). Conclusion: The intraarterial chemotherapy can reduce the expression of VEGF and MVD, and adjust malignancy of cervical cancer, and cut down the postoperative metastasis.