50—60年代,学者们对“细胞免疫的转移”问题曾做了大量的工作,以寻找实验动物模型,但大多数不成功。Bloom及Charse所复习的早期文献说明在小啮齿动物中的试验完全无作用,因而Lawrence(1969)断言,“转移因子(TF)在体内,种与种之间不能交叉转移”。 In the 1950s and 1960s, a great deal of work has been done by scholars on the issue of “cellular immune transfer” to find experimental animal models, but most of them failed. Earlier articles reviewed by Bloom and Charse showed no effect at all in small rodents and Lawrence (1969) concluded that “TFs can not cross-metastasize in vivo, between species and species.”