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目的探讨孕酮对大鼠颌下腺表皮生长因子（ＥＧＦ）及其受体（ＥＧＦＲ）表达的影响。方法用免疫组化方法观察注射１，３，５和７天孕酮后，成年雌性ＳＤ大鼠颌下腺ＥＧＦ、ＥＧＦＲ表达及颗粒曲管（ＧＣＴ）形态的改变。结果与对照组比较，注射孕酮１天组，ＥＧＦ的阳性表达最强，３天组较强，５天组减弱，７天组复又增强；ＥＧＦＲ的表达１，３天组减弱，５天组增强，７天组复又减弱，与ＥＧＦ的表达基本相反。ＧＣＴ最宽径及细胞高度的变化与ＥＧＦＲ的变化基本一致，或滞后出现。结论孕酮促进大鼠颌下腺ＧＣＴ合成ＥＧＦ，ＥＧＦ与ＥＧＦＲ之间存在反向调节，ＧＣＴ的变化与ＥＧＦＲ的含量有关。
Objective To investigate the effect of progesterone on the expression of epidermal growth factor (EGF) and its receptor (EGFR) in the submandibular gland of rats. Methods Immunohistochemistry was used to observe the morphological changes of EGF, EGFR and GCT in submandibular glands of adult female SD rats after 1, 3, 5 and 7 days of progesterone injection. Results Compared with the control group, the positive expression of EGF was the strongest in the first day of progesterone injection. The expression of EGF was stronger in the third day group, weakened in the fifth day group and increased in the seventh day group. The expression of EGFR was weakened in the first and third days Group increased, 7 days group complex and weakened, and EGF expression is basically the opposite. The changes of the widest width and height of GCT were basically the same as those of EGFR, or lagged. Conclusion Progesterone promotes the reverse regulation of EGF, EGF and EGFR synthesis in GCT of rat submandibular gland, and the change of GCT is related to the content of EGFR.