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通过相溶解度方法研究了β-环糊精(β-CD)与七-(2,6-二-O-甲基)-β-环糊精(DM-β-CD)对苏丹红染料Ⅰ~Ⅳ的增溶。紫外可见光谱数据表明,β-CD与DM-β-CD浓度的增加对于苏丹红I~III的溶解度并无影响,但可以增加苏丹红Ⅳ的水溶性。实验结果表明,溶液中β-CD或DM-β-CD能够与苏丹红IV形成化学计量比为1:1的非共价复合物,从而增加苏丹红IV的溶解度。通过分子对接研究可知,疏水与氢键作用是苏丹红IV同β-CD或DM-β-CD形成复合物的驱动力。
The effects of β-CD and hepta-2,6-di-O-methyl-β-cyclodextrin (DM-β-CD) IV solubilization. UV-vis data showed that the increase of β-CD and DM-β-CD concentration had no effect on the solubility of Sudan I to III, but could increase the water solubility of Sudan IV. The experimental results show that β-CD or DM-β-CD in solution can form non-covalent complexes with Sudan IV in a stoichiometric ratio of 1: 1, thereby increasing the solubility of Sudan IV. By molecular docking study shows that hydrophobic and hydrogen bonding is the driving force Sudan IV with β-CD or DM-β-CD complex formation.