论文部分内容阅读
制作帕金森氏病大鼠模型，观察其黑质区注射徽量神经降压素后的效应。结果表明：（１）黑质区注射６－羟基多巴胺２ｌ天后，大鼠出现帕金森氏病的行动迟缓、强直和震颤等三大症状，以及股四头肌肌电图群放电位频率为４～８次／ｓ的动物模型；（２）黑质区注射不同剂量的神经降压素，经过一定时间后，大鼠模型的强直和震颤症状出现不同程度改善，且呈明显量效依赖关系，而其行动迟缓症状改善不明显。提示，黑质区外源性神经降压素具有一定的抗帕金森氏病效应。
The rat model of Parkinson’s disease was made to observe the effect of the injection of warfarin on the substantia nigra region. The results showed that: (1) After the rats were injected with 6-hydroxy-dopamine for 21 days in the substantia nigra, there were three symptoms of Parkinson’s disease, such as tardive action, tonicity and tremor, and the frequency of discharge potentials of quadriceps electromyogram ~ 8 times / s animal models; (2) injection of different doses of neurotensin in the substantia nigra region, after a certain period of time, rat models of tonic and tremor symptoms appear to varying degrees of improvement, and showed a dose-dependent relationship, However, the symptoms of delayed onset were not obvious. Tip, nigral extrinsic neurotensin has anti-Parkinson’s disease effect.