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目的探讨整合素连接激酶(ILK)在正常卵巢、卵巢良性肿瘤、卵巢交界性肿瘤、卵巢癌组织中的表达及其临床意义。方法1999年1月至2006年12月在沧州中西医结合医院采用免疫组化SP法检测正常卵巢组织10例,良性卵巢肿瘤20例,交界性肿瘤28例,卵巢癌86例中整合素连接激酶的表达。结果ILK蛋白在卵巢癌、交界性肿瘤、良性肿瘤组织中的表达差异有显著性意义(P<0.05)。结论ILK在卵巢恶性肿瘤的发生发展中起重要作用,检测ILK的表达有助于判断肿瘤的生物学行为及预后。
Objective To investigate the expression of integrin - linked kinase (ILK) in normal ovary, benign ovarian tumor, borderline ovarian tumor and ovarian cancer and its clinical significance. Methods From January 1999 to December 2006, 10 cases of normal ovarian tissue, 20 cases of benign ovarian tumor, 28 cases of borderline tumor and 86 cases of ovarian cancer were detected by immunohistochemical SP method in Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine. expression. Results The expression of ILK protein in ovarian cancer, borderline tumors and benign tumors was significantly different (P <0.05). Conclusion ILK plays an important role in the occurrence and development of ovarian cancer. Detecting the expression of ILK will help to determine the biological behavior and prognosis of ovarian cancer.