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目的目的探讨我院左氧氟沙星常见不良反应的原因、预防建议及措施。方法选取2010~2014年我院住院患者静脉使用左氧氟沙星注射液发生的88例不良反应报告,根据患者的一般情况、给药剂量、累及部位进行统计分析,总结其发生的特征并给予针对性的预防建议及措施。结果 88例不良反应中老年患者比例高于中青年患者,差异有统计学意义(P<0.05)。不良反应累及部位中皮肤损害最多,与其他部位比较,差异有统计学意义(P<0.05)。结论左氧氟沙星注射液不良反应的发生与药物本身、患者的年龄以及给药剂量、给药速度、浓度均存在一定程度的相关性,临床给药时需谨慎,进而提高安全程度,降低危险度。
Objective To investigate the causes, prevention and treatment of common adverse reactions of levofloxacin in our hospital. Methods A total of 88 adverse reactions were reported in our hospital from year 2010 to 2014. The patients were given routine doses of levofloxacin and their dose and location were statistically analyzed. The characteristics of the patients were summarized and their preventive measures were given Suggestions and measures. Results The proportion of 88 patients with ADR was higher than that of middle-aged and young patients (P <0.05). Side effects of adverse reactions in the most skin lesions, compared with other parts, the difference was statistically significant (P <0.05). Conclusion The incidence of adverse reactions of levofloxacin injection is related to the drug itself, the patient’s age, administration dose and administration speed and concentration, and should be cautious in clinical administration to improve the safety and reduce the risk.