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目的:研究乙肝免疫球蛋白对乙肝感染孕妇的宫内阻断作用。方法:筛选乙肝病毒携带者孕妇208例,分成乙肝免疫球蛋白注射组、生理盐水注射组和不注射组(无干预组),ELISA方法测定新生儿脐血乙肝表面抗原,以及荧光定量PCR分析脐血乙肝DNA含量。结果:乙肝免疫球蛋白注射组脐血HBsAg阳性率为27.38%(17/68),DNA检测阳性率(DNA含量>103COPYS/L记阳性)为22.06%(15/68);生理盐水注射组为91.43%(64/70)、87.14%(61/70);无干预组为90.00%(63/70)、88.57%(62/70)。HBsAg阳性率,乙肝免疫球蛋白注射组与生理盐水注射组(χ2=61.14,P<0.005)和不注射组(χ2=59.81,P<0.005)比较均差异有统计学意义;DNA检测阳性率,乙肝免疫球蛋白注射组与生理盐水注射组(χ2=59.05,P<0.005)和不注射组(χ2=61.86,P<0.005)比较均差异有统计学意义。结论:多次乙肝免疫球蛋白注射可有效阻断乙肝的宫内感染。
Objective: To study the intrauterine blocking effect of hepatitis B immunoglobulin on pregnant women with hepatitis B infection. Methods: 208 pregnant women with hepatitis B virus were screened and divided into hepatitis B immunoglobulin injection group, saline injection group and non-injection group (without intervention group). ELISA was used to determine the HBsAg in newborns and fluorescent quantitative PCR Hepatitis B DNA content. Results: The positive rate of HBsAg in cord blood was 27.38% (17/68) in HBIG group and 22.06% (15/68) in DNA positive group (DNA content> 103COPYS / L) 91.43% (64/70) and 87.14% (61/70) respectively. The non-intervention group was 90.00% (63/70) and 88.57% (62/70). The positive rates of HBsAg, hepatitis B immunoglobulin injection group and saline injection group (χ2 = 61.14, P <0.005) and no injection group (χ2 = 59.81, P <0.005) There was significant difference between hepatitis B immunoglobulin injection group and saline injection group (χ2 = 59.05, P <0.005) and no injection group (χ2 = 61.86, P <0.005). Conclusion: Multiple hepatitis B immunoglobulin injections can effectively prevent hepatitis B intrauterine infection.