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目的通过比较抗菌药物专项整治活动对某三甲医院结直肠癌手术患者在2010年、2012年和2015年抗菌药物应用的影响,评价抗菌药物使用的合理性,促进临床合理用药。方法以回顾性调查的方法,随机抽取相应年度该院结直肠癌手术患者出院病历各100份,设计相关调查表格对抗菌药物使用率、品种、剂量、疗程等指标进行统计分析,评价抗菌药物使用的合理性。结果患者住院期间抗菌药物累计DDD数有小幅下降,分别为1 251 DDD、1 201 DDD和1 171 DDD,抗菌药物使用强度(单位:DDD/100人·天)有所增加,分别为56.11、61.01和67.31,术中给药时机合理率分别为12%、70%和92%,预防用抗菌药物选择合理率分别为59%、94%和97%。结论通过比较5年间结直肠癌手术患者抗菌药物应用的变化,可见抗菌药物专项整治活动的开展有显著的影响和明显的成效,但仍存在抗菌药物使用强度较高的不合理现象,应进一步加强临床药学服务与干预,促进抗菌药物的合理使用。
Objective To evaluate the rational use of antibacterials and promote the rational use of antibiotics by comparing the effects of antibacterials special rectification activities on the use of antibacterials in patients with colorectal cancer in a top three hospital in 2010, 2012 and 2015. Methods A retrospective survey of randomly selected from the hospital for the corresponding annual discharge of patients with colorectal cancer in the 100 medical records, design-related survey forms antibiotics use rate, variety, dose, duration and other indicators of statistical analysis to evaluate the use of antimicrobial agents The rationality. Results The cumulative number of DDDs in patients during hospitalization decreased slightly to 1 251 DDD, 1 201 DDD and 1 171 DDD, respectively. The strength of antimicrobial agents (unit: DDD / 100 persons · day) increased slightly, reaching 56.11 and 61.01 respectively And 67.31 respectively. The reasonable timing of intraoperative administration was 12%, 70% and 92% respectively. The reasonable rates of prophylactic antimicrobial agents were 59%, 94% and 97% respectively. Conclusions By comparing the application of antimicrobial agents in patients with colorectal cancer during 5 years, we can see that the special rectification activities of antimicrobial agents have a significant impact and significant results, but there is still an irrational phenomenon that the use of antimicrobial agents is relatively high and should be further strengthened Clinical Pharmacy Services and Interventions to Promote the Rational Use of Antibacterials.