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目的了解我国农村地区HIV阳性人群合并弓形虫感染现状,以及合并感染与CD4+T淋巴细胞的关系。方法按1:1匹配的方式,在现场招募HIV阳性感染者和HIV阴性对照624人作为研究对象,采集其外周血样本,采用ELISA法检测弓形虫抗体,并检测其体内CD4+T淋巴细胞水平。结果共对604人同时进行了弓形虫抗体和CD4+T淋巴细胞水平检测,HIV阳性人群弓形虫抗体阳性率为1.32%,阴性对照人群弓形虫抗体阳性率为0.33%,两者差异无统计学意义(P>0.05)。HIV阳性感染者中,合并和未合并弓形虫感染者体内CD4+T淋巴细胞水平分别为(446.75±177.25)个/μl和(413.55±243.37)个/μl,两者差异无统计学意义。结论当地一般人群和HIV阳性人群弓形虫感染率均较低,弓形虫感染与HIV阳性人群体内CD4+T淋巴细胞水平之间的关系有待进一步研究。
Objective To understand the prevalence of Toxoplasma gondii infection in HIV-positive population in rural areas of China, and the relationship between co-infection and CD4 + T lymphocytes. Methods A total of 624 HIV-positive and HIV-negative controls were recruited in the field as 1: 1 matching test. Peripheral blood samples were collected and tested for antibody against Toxoplasma gondii by ELISA. CD4 + T lymphocyte levels . Results Toxoplasma gondii antibody and CD4 + T lymphocyte levels were detected in 604 patients at the same time. The positive rate of Toxoplasma gondii antibody in HIV-positive population was 1.32%, while the positive rate of Toxoplasma gondii antibody in negative control group was 0.33%. There was no significant difference between the two Significance (P> 0.05). Among HIV-positive patients, the levels of CD4 + T lymphocytes in infected and non-infected Toxoplasma gondii were (446.75 ± 177.25) / μl and (413.55 ± 243.37) / μl, respectively, with no significant difference between the two groups. Conclusion The prevalence of Toxoplasma gondii in both general population and HIV-positive population is low. The relationship between Toxoplasma gondii infection and CD4 + T lymphocyte level in HIV-positive population remains to be further studied.