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在艾滋病相关性、非洲地方性和经典散发性Kaposi肉瘤中均检测到人疱疹病毒8型(HHV-8),因而该病毒被看作Kaposi肉瘤发生的病因。家族性Kaposi肉瘤罕见,人们认为该病的发生主要由遗传因素决定,可能与HHV-8无关。作者采用巢式PCR和DNA测序方法,对2例家族性Kaposi肉瘤的病理活检组织作了HHV-8的特异性DNA序列(KS330 Bam序列)检测和分析。2例患者系同胞兄妹,在两个月内先后发病。结果2例患者均检测到HHV-8 KS330 Bam DNA 片断,序列分析表明其DNA
Herpesvirus 8 (HHV-8) has been detected in HIV-associated, African endemic and classical sporadic Kaposi’s sarcomas, and the virus is thus considered to be the cause of Kaposi’s sarcoma. Familial Kaposi’s sarcoma is rare and it is thought that the occurrence of the disease is mainly determined by genetic factors and may not be related to HHV-8. The authors used nested PCR and DNA sequencing methods to detect and analyze the specific DNA sequence (KS330 Bam sequence) of HHV-8 in two cases of familial Kaposi’s sarcoma. Two patients were siblings and had a history of two months. Results The HHV-8 KS330 Bam DNA fragment was detected in both patients. Sequence analysis showed its DNA.