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目的 回顾性分析比较单孔胸腔镜下肺叶切除术与常规三孔胸腔镜术式的临床疗效,为早期周围型肺癌微创手术方式的选择提供参考.方法 选取苏州大学附属第一医院胸外科2016年1月—2016年12月周围型肺癌手术病例118例,按手术方式分为单孔手术组与三孔手术组,比较两组手术时间、淋巴结清扫数目、术中失血量、胸管引流量、术后置管天数、术后住院天数、围手术期并发症发生率、术后疼痛评分等指标的差异.结果 两组患者在性别、年龄上差异无统计学意义(P>0.05);单孔手术组与三孔手术组淋巴结清扫数目[(12.89±2.24)个vs(13.37±1.79)个]、术中失血量[(148.11±41.56)mL vs(158.77±45.05)mL]、术后胸管总引流量[(708.30±163.21)mL vs(762.44±170.92)mL]、术后胸管置管时间[(4.19±1.35)d vs(4.43±1.56)d]、术后住院天数[(6.96±1.62)d vs(7.34±1.75)d]、围术期并发症发生率(15.1％vs 15.4％)差异均无统计学意义(P>0.05).单孔手术组与三孔手术组手术时间[(142.83±29.43)min vs(129.08±30.40)min]、术后24 h疼痛评分[(4.85±1.63)分vs(5.95±1.86)分]、术后72 h疼痛评分[(1.54±1.14)分vs(2.20±1.18)分],差异有统计学意义(P0.05). There was no statistical difference in lymph node dissection number [(12.89±2.24) vs. (13.37±1.79)], intraoperative blood loss [(148.11±41.56) mL vs. (158.77±45.05) mL], pleural canals drainage [(708.30±163.21) mL vs. (762.44±170.92) mL], pleural canals duration time [(4.19±1.35) d vs. (4.43±1.56) d],postoperative hospital stay [(6.96±1.62) d vs. (7.34±1.75) d], perioperative period postoperative complications rate (15.1％ vs. 15.4％) between the two groups (P>0.05). There were statistical differences in operation time [(142.83±29.43) min vs. (129.08±30.40) min], degree of chest pain within 24 h after operation [(4.85±1.63) vs. (5.95±1.86)] and degree of chest pain within 72 h after operation [(1.54±1.14) vs. (2.20±1.18)] between the two groups (P<0.05). Conclusion Single-port VATS can reach the same curative effect as the traditional three-port VATS in early peripheral lung cancer, and is superior to three-port VATS in postoperative pain. Single-port VATS is a very promising operative type.