细胞周期蛋白控制细胞周期的运转，从而决定细胞的增生、肥大及凋亡等。Ｐ２７是其中一种十分重要的细胞周期负调控蛋白，近年来研究表明其不仅调控着肾脏的发育过程，而且与肾脏疾病的发生、发展密切相关。本文就近年来的相关资料进行综述。 Cyclins control the operation of the cell cycle to determine cell proliferation, hypertrophy and apoptosis. P27 is one of the most important cell cycle negative regulatory proteins. In recent years, studies have shown that P27 not only regulates the development of the kidney, but also is closely related to the occurrence and development of kidney disease. This article summarizes the relevant information in recent years.