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目的分析依达拉奉对急性脑梗死患者神经元特异性烯醇化酶水平的影响。方法选取本院2012年10月—2015年3月收治的62例急性脑梗死患者作为研究对象,根据随机原则分成常规组和试验组。常规组患者予以常规疗法,试验组患者加用依达拉奉,每次30 mg依达拉奉+氯化钠注射液250 ml,静脉滴注,2次/d,治疗14 d。对比两组患者治疗效果,并在治疗前后对神经功能缺损评分(national institute of health stroke scale,NHISS)、神经元特异性烯醇化酶水平的差异进行对比。计量资料采用t检验,计数资料采用χ~2检验,P<0.05为差异有统计学意义。结果与常规组有效率(70.97%)相比,试验组有效率为90.32%,对比差异有统计学意义(P<0.05)。干预后试验组NHISS、神经元特异性烯醇化酶水平显著优于常规组[(13.18±1.12)、(17.83±1.21)分、(11.18±0.51)、(23.43±0.29)ng/ml],对比差异均有统计学意义(均P<0.05)。结论依达拉奉对急性脑梗死患者效果确切,可有效改善患者神经元特异性烯醇化酶水平和神经功能,值得推广。
Objective To analyze the effect of edaravone on the level of neuron-specific enolase in patients with acute cerebral infarction. Methods Sixty-two patients with acute cerebral infarction who were treated in our hospital from October 2012 to March 2015 were selected as the research subjects and divided into the routine group and the experimental group according to the random principle. Patients in the conventional group were treated with edaravone. Patients in the test group were treated with edaravone 30 mg each by 250 ml intravenous drip twice a day for 14 days. The therapeutic effect was compared between the two groups, and the differences in the levels of the national institute of health stroke scale (NHISS) and neuron-specific enolase were compared before and after treatment. Measurement data using t test, count data using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results Compared with the conventional group (70.97%), the effective rate of the experimental group was 90.32%, the difference was statistically significant (P <0.05). After intervention, the levels of NHISS and neuron-specific enolase in the experimental group were significantly better than those in the conventional group [(13.18 ± 1.12), (17.83 ± 1.21), (11.18 ± 0.51), (23.43 ± 0.29) ng / ml] The differences were statistically significant (all P <0.05). Conclusion Edaravone is effective in patients with acute cerebral infarction, which can effectively improve the level of neuron-specific enolase and neurological function, which is worth promoting.