目的:虽然光动力疗法(photodynamic therapy,PDT)在多种肿瘤治疗中得到了广泛应用,然而预测PDT疗效的理想剂量学指标仍然缺乏。本研究探讨了反应性单态氧(~1O_2]rx)作为PDT疗效预测指标的可行性,并与PDT剂量(PDT dose)和PDT能量密度对PDT疗效的影响进行比较。方法:以皮下接种RIF细胞的C3H小鼠为动物模型,在静脉给予5 mg/kg Photofrin后24 h,将微透镜光纤与630 nm PURPOSE: Although photodynamic therapy (PDT) is widely used in a variety of oncology therapies, the ideal dosimetric markers for predicting the efficacy of PDT are still lacking. This study explored the feasibility of reactive singlet oxygen (~ 1O_2] rx) as a predictor of efficacy of PDT and compared the effects of PDT dose and PDT energy density on the efficacy of PDT. METHODS: C3H mice were inoculated with RIF cells subcutaneously as an animal model. Microinfibers were incubated with 630 nm