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目的探究难治疗性哮喘病患者血清中肿瘤坏死因子的α水平以及其在临床上的意义。方法随机选取2010年7月至2012年3月在本院进行治疗的哮喘患者共计62例进行实验,探究难治性哮喘患者以及一般哮喘患者血清中肿瘤坏死因子的α水平以及相关临床指标。结果难治性哮喘病患者血清中肿瘤坏死因子的α水平高于一般哮喘患者,两组患者在治疗前以及治疗之后两组患者的一秒用力呼吸容积、哮喘控制测试评分之间的差异具有统计学意义,P<0.05。两组患者在治疗过程中每天的糖皮质激素平均用量之间的差异没有统计学意义,P>0.05。结论哮喘病患者血清中肿瘤坏死因子的α水平能够反应患者的病情以及治疗效果。
Objective To investigate the serum level of tumor necrosis factor alpha in refractory asthma patients and its clinical significance. Methods A total of 62 asthmatic patients treated in our hospital from July 2010 to March 2012 were randomly selected to study the levels of serum tumor necrosis factor α and related clinical indexes in patients with refractory asthma and general asthma. Results The levels of serum tumor necrosis factor alpha in patients with refractory asthma were higher than those in patients with asthma. The differences in one-second forced respiration volume and asthma control test scores between the two groups before and after treatment were statistically significant Significance, P <0.05. There was no significant difference between the two groups in the daily glucocorticoid dosage during treatment, P> 0.05. Conclusion The level of tumor necrosis factor α in serum of patients with asthma can reflect the patient’s condition and the therapeutic effect.