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目的:分析抗N-甲基-D-天冬氨酸(anti-N-methyl-D-aspartate,NMDA)受体脑炎的发病机制及临床特征,提高该病的诊治水平,减少后遗症。方法:对我院诊治的抗NMDA受体脑炎的临床资料进行回顾性分析,并根据此病例复习相关文献,总结经验。结果:患者因“言语混乱15天,意识不清1天”收入我院。行脑脊液及血液检查抗NMDA受体抗体阳性,给予糖皮质激素、免疫球蛋白、免疫抑制剂治疗,病情较之前显著改善,且任何的后遗症均未留下。结论:抗NMDA受体脑炎在临床上的发病率比较低,我们需提高对此病的认识,减少误诊。
Objective: To analyze the pathogenesis and clinical features of anti-N-methyl-D-aspartate (NMDA) receptor encephalitis, to improve the diagnosis and treatment of the disease and reduce the sequelae. Methods: The clinical data of anti-NMDA receptor encephalitis diagnosed and treated in our hospital were retrospectively analyzed. Based on this case, the related literatures were reviewed and the experience was summarized. Results: Patients because “15 days confusion, confusion 1 day ” income in our hospital. Cerebrospinal fluid and blood tests anti-NMDA receptor antibody positive, given glucocorticoid, immunoglobulin, immunosuppressive therapy, the condition significantly improved than before, and no sequelae left behind. Conclusion: The incidence of anti-NMDA receptor encephalitis in the clinic is relatively low, we need to raise awareness of the disease and reduce misdiagnosis.