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目的观察奥美拉唑联合曲美布汀治疗返流性食管炎临床疗效。方法将120例返流性食管炎患者随机分为3组:曲美布汀组40例,奥美拉唑组40例,奥美拉唑和曲美布联合汀治疗组40例,3组在性别、年龄、病程、病情等方面无明显差异性(P>0.05)。曲美布汀组给予曲美布汀0.1g,3次/d,餐前口服,一周为一疗程,共3周。奥美拉唑组给予奥美拉唑20mg,2次/d,餐前口服,一周为一疗程,共3周。奥美拉唑和曲美布汀治疗组给予曲美布汀0.1g,3次/d,餐前口服;同时服奥美拉唑20mg,2次/d,餐前口服。一周为一疗程,共3周。结果 3组经治疗后自觉症状和内镜下表现均有改善,但奥美拉唑和曲美布汀联合治疗组疗效明显。结论奥美拉唑和曲美布汀联合治疗较单独应用疗效好,无明显不良反应,值得临床推广应用。
Objective To observe the clinical efficacy of omeprazole and trimebutine in the treatment of reflux esophagitis. Methods A total of 120 patients with reflux esophagitis were randomly divided into 3 groups: 40 patients in trimebutine group, 40 patients in omeprazole group, 40 patients in omeprazole and trimebutine combined group, and 3 patients in control group There was no significant difference in gender, age, course of disease, illness, etc. (P> 0.05). Trimebutine group Trimebutine 0.1g, 3 times / d, pre-meal oral, a week for a course of treatment, a total of 3 weeks. Omeprazole group given omeprazole 20mg, 2 times / d, before meals, a week for a course of treatment, a total of 3 weeks. Omeprazole and trimebutine treatment group trimebutine 0.1g, 3 times / d, before meals; at the same time taking omeprazole 20mg, 2 times / d, before meals. One week for a course of treatment, a total of 3 weeks. Results After the treatment, the symptoms and endoscopic findings improved, but the combination of omeprazole and trimebutine was effective. Conclusion Combination of omeprazole and trimebutine is more effective than single use, with no obvious adverse reactions, which is worthy of clinical application.