【摘 要】
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Multiple sclerosis (MS) is a complex chronic disease of the central nervous system (CNS) which includes three main anatomopatho-logical characteristics: inflamm
【机 构】
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Instituto de Medicina Translacional e Ingeniería Biomédica delHospital italiano(IMTIB-CONICET),Leloi
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Multiple sclerosis (MS) is a complex chronic disease of the central nervous system (CNS) which includes three main anatomopatho-logical characteristics: inflammation, demyelination, neurodegener-ation. This pathology induces many clinical symptoms, depending on the site of the lesions, such as motor, sensitive, visual, urinary and cognitive manifestations. In addition, MS is a very heteroge-neous disease that displays different clinical courses or phenotypes (relapsing/remitting MS, primary progressive MS (PPMS) and secondary progressive MS (SPMS). Both neurodegeneration and inflammation are present along the natural history of the disease. However, the balance of both phenomena varies according to the course of the disease. In relapsing/remitting MS form, the acute inflammation, mainly adaptive immunity, predominates over the neurodegeneration, being the main cause of the relapses. In SPMS and PPMS, the neurodegeneration predominates over the inflam-mation, which appears as chronic inflammation, being innate immunity (microglia and astroglia) the main feature in the neuro-degenerative process.
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