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三苯氧胺(TMX)为非甾体类抗雌激素药物,20年前,首先作为绝经后晚期乳腺癌患者的姑息性治疗,而今,TMX可为各期乳腺癌选择病例提供有益的内分泌治疗.同时已有计划的应用于乳腺癌高危人群,以评价其对乳腺癌预防性治疗的价值.1977年,在英国剑桥会议,实验室研究结果就支持对高危女性乳腺癌辅以长期TMX治疗,可能获得最有益的结果.当时,几组为期1年的TMX辅助治疗研究是基于:①TMX使
Tamoxifen (TMX) is a non-steroidal anti-estrogen drug. Twenty years ago, it was first used as a palliative treatment for postmenopausal patients with advanced breast cancer. Today, TMX can provide beneficial endocrine therapy for selected cases of breast cancer. It is planned to be used in high-risk groups for breast cancer to evaluate its value for preventive treatment of breast cancer. In 1977, at the Cambridge Conference in the United Kingdom, laboratory findings supported the use of long-term TMX therapy for breast cancer in high-risk women, possibly obtaining the most Beneficial results. At that time, several groups of 1-year TMX adjuvant therapy studies were based on: 1 TMX