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目的:分析米非司酮与去氧孕烯炔雌醇对围绝经期患者功能失调性子宫出血的疗效及安全性。方法:选取2014年2月—2016年11月间收治的围绝经期功能失调性子宫出血患者78例,采用随机数表法将其分为对照组和治疗组,每组39例;对照组患者给予米非司酮治疗,治疗组患者在对照组基础上加用去氧孕烯炔雌醇治疗,评价两组患者治疗2月后的总有效率、不良反应的发生率及其治疗前后促卵泡生成素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕酮(P)测得值的变化情况。结果:治疗组患者治疗后的总有效率为97.44%高于对照组为71.79%(P<0.05);治疗后两组患者FSH、LH、E2、P测得值均低于治疗前(P<0.05);治疗组患者治疗后FSH、LH、E2、P测得值低于对照组(P<0.05)、不良反应的发生率为7.69%低于对照组为30.77%(P<0.05)。结论:采用米非司酮与去氧孕烯炔雌醇联用治疗围绝经期患者功能失调性子宫出血,疗效较显著,安全性较高。
Objective: To analyze the curative effect and safety of mifepristone and deoxygregate ethinyl estradiol on dysfunctional uterine bleeding in perimenopausal patients. Methods: Seventy-eight patients with peri-menopausal dysfunctional uterine bleeding who were admitted between February 2014 and November 2016 were randomly divided into control group and treatment group, 39 cases in each group. Patients in the control group To give mifepristone treatment, the treatment group patients in the control group based on plus use of desogestrel ethinyl estradiol treatment, evaluation of two groups of patients after 2 months of treatment of total effective rate, the incidence of adverse reactions and follicle stimulation before and after treatment (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P) measured value changes. Results: After treatment, the total effective rate of the treatment group was 97.44%, which was significantly higher than that of the control group (71.79%, P <0.05). The values of FSH, LH, E2 and P in the two groups after treatment were lower than those before treatment (P < 0.05). The measured values of FSH, LH, E2 and P in the treatment group were lower than those in the control group (P <0.05). The incidence of adverse reactions was 7.69%, which was lower than that of the control group (30.77%, P <0.05). Conclusion: The combination of mifepristone and desogestrel ethinyl estradiol in the treatment of dysfunctional uterine bleeding in patients with perimenopausal period, the effect is more significant and safe.