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Shen Yuan Gan(SYG)is a Chinese herbal prescription composed of total saponins of Panax ginseng and total oligosaccharide esters of Polygala tenuifolia(2:1).Our previous studies have demonstrated that SYG has antidepressant-like effects in various mouse models of behavioral depression.The present study aimed to test whether SYG affected chronic mild stress(CMS)-induced depression and cognitive impairment in mice.We found that a 5-week CMS schedule induced significant degradation of the coat state,decreased sucrose intake in the sucrose-preference test,and increased the latency to feed in the noveltysuppressed feeding test.All of these CMS-induced changes were ameliorated by SYG(100 and 200mg/kg)and fluoxetine(10 mg/kg).In addition,SYG restored the decreased monoamine neurotransmitter concentrations(serotonin,dopamine,norepinephrine and acetylcholine)induced by CMS in the prefrontal cortex.Interestingly,SYG ameliorated CMS-induced cognitive impairment in the step-through test,and increased the acetylcholine level in the prefrontal cortex.These results suggest that SYG has an antidepressant-like action and enhances cognition by modulating the serotonin,dopamine,norepinephrine,and acetylcholine levels in the prefrontal cortex.
Shen Yuan Gan (SYG) is a Chinese herbal medicine composed of total saponins of Panax ginseng and total oligosaccharide esters of Polygala tenuifolia (2: 1). Our previous studies have the that that SYG has antidepressant-like effects in various mouse models of behavioral depression The present study aimed to test whether SYG affected chronic mild stress (CMS) -induced depression and cognitive impairment in mice. We found that a 5-week CMS schedule induced significant degradation of the coat state, decreased sucrose intake in the sucrose-preference test, and increased the latency to feed in the noveltysuppressed feeding test. All of these CMS-induced changes were ameliorated by SYG (100 and 200 mg / kg) and fluoxetine (10 mg / kg) .In addition, SYG restored the decreased monoamine neurotransmitter concentrations (serotonin, dopamine, norepinephrine and acetylcholine) induced by CMS in the prefrontal cortex.Interestingly, SYG ameliorated CMS-induced cognitive impairment in the step-through test, and increas ed the acetylcholine level in the prefrontal cortex.These results suggest that SYG has an antidepressant-like action and enhance cognition by modulating the serotonin, dopamine, norepinephrine, and acetylcholine levels in the prefrontal cortex.