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目的深入分析2013年辽宁省手足口病例的病原监测资料,掌握本地区病原分布特征及影响监测结果的因素。方法收集辽宁地区手足口病例样本的核酸检测资料,应用描述流行病学方法进行分析,地区分布则采用系统聚类分析,根据离差平方和法进行判定。结果 2013年辽宁省手足口病的病原分布以其他肠道病毒为主,病原谱具有地区差异。1~6岁年龄组的病原构成决定本地区的病原谱。在采样至检测时间>28d的条件下,发病至采样时间与样本阳性检出率呈负相关(r=-0.770,P<0.05)。结论手足口病病原监测以1~6岁年龄组为主要对象,根据实际情况尽量采集病例发病7d内的样本,采样至检测的时间<28d的阳性检出效果较好。
Objective To analyze in depth the pathogen monitoring data of cases of hand, foot and mouth in Liaoning Province in 2013, and to grasp the distribution characteristics of pathogens and the factors that affect the monitoring results in this area. Methods The nucleic acid test data of hand, foot and mouth cases in Liaoning Province were collected and analyzed by descriptive epidemiological methods. The regional distribution was analyzed by systematic clustering, and the method of variance sum of squares was used to judge. Results The pathogen distribution of HFMD in Liaoning Province in 2013 was dominated by other enteroviruses. There were regional differences in pathogen spectrum. The pathogens of the 1 ~ 6 age group determine the pathogenic spectrum in this area. There was a negative correlation between the sampling time and the positive detection rate (r = -0.770, P <0.05) when the sampling time was longer than 28 days. Conclusion The pathogens of hand-foot-mouth disease were mainly detected in the age group of 1 to 6 years. Samples were collected within 7 days according to the actual situation. The positive results of sampling to detection time <28 days were better.