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目前已建立孕中期检测母体血清中生物化学参数来筛查Down氏综合征(DS)和其它染色体非整倍体疾病。在此经验的基础上,一些研究人员又探讨在孕早期选择绒毛采样(CVS)之前进行筛查的可能性。Brambati等人提出在妊娠的DS中母体血清中α二醇及α-胎蛋白(AFP)要比染色体正常妊娠都低。 对2 471名孕早期妇女进行了母体血清AFP(MSAFP)测定,这种方法显然优于绒毛采样。数据分析表明,在DS妊娠中MSAFP的平均浓度要比正常妊娠低。不论将其临界水平确定在0.5倍正常中值(MOM)还是0.6倍MOM,都不适于高风险下DS的妊娠识别。研究人员还对妊娠
Biochemical parameters in maternal serum have now been established for second trimester screening for Down’s syndrome (DS) and other chromosomal aneuploidy diseases. Based on this experience, some researchers also explore the possibility of screening before selecting villus sampling (CVS) in early pregnancy. Brambati et al. Suggest that maternal serum alpha-fetoprotein (AFP) and alpha-fetoprotein (AFP) are lower in normal DS than in normal pregnancy. The maternal serum AFP (MSAFP) assay was performed in 2 471 pregnant women in early pregnancy, which is clearly superior to villus sampling. Data analysis showed that the mean concentration of MSAFP in DS pregnancies was lower than in normal pregnancies. Regardless of their critical level at 0.5 times the normal median (MOM) or 0.6 times the MOM, are not suitable for pregnancy at high risk of DS identification. Researchers also on pregnancy