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目的观察老年心脑血管患者长期应用阿司匹林的安全性。方法 2004年1月至2009年1月,在吉林市中心医院特诊一疗区住院的老年心脑血管患者共232例。对232例分别进行12个月、3年和5年的随访。随访内容包括:阿司匹林的应用情况及有无不良反应。选取的患者在12个月、3年和5年,分别进行头部CT、心电图等检查并测定出血尿常规、凝血时间、肝功能、肾功能。结果随访232例中,209例坚持服用阿司匹林至少12个月,不良反应:消化道反应32例,皮疹0例,轻微出血或发生血小板减少15例,大出血0例,无肝肾功能损害。患者用药依从性达96%。结论老年心脑血管患者长期应用阿司匹林,依从性好,不良反应少,但仍需监测。
Objective To observe the long-term safety of aspirin in elderly patients with cardiovascular and cerebrovascular diseases. Methods From January 2004 to January 2009, a total of 232 elderly patients with cardiovascular and cerebrovascular disease were hospitalized in the special treatment area of Jilin Central Hospital. 232 cases were followed up for 12 months, 3 years and 5 years respectively. Follow-up includes: the application of aspirin and whether the adverse reactions. Selected patients at 12 months, 3 years and 5 years, head CT, ECG and other tests and determination of hematuria, clotting time, liver function, renal function. Results 232 cases were followed up, 209 patients insisted on taking aspirin for at least 12 months, adverse reactions: 32 cases of gastrointestinal reactions, rash 0 cases, mild bleeding or thrombocytopenia in 15 cases, 0 cases of bleeding, no liver and kidney dysfunction. Patient medication compliance up to 96%. Conclusion Long-term aspirin in elderly patients with cardiovascular and cerebrovascular diseases, good compliance, fewer adverse reactions, but still need monitoring.