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A lossy mode resonance (LMR)-supported fiber optic sensor in which a uniform fiber core is placed among two identical tapered regions,is investigated numerically.Indium tin oxide (ITO) and aluminum-doped zinc oxide (AZO) are considered as LMR active materials used to excite several lossy modes and gold and silver are used as surface plasmon resonance (SPR) active materials.In this probe design,a central uniform core coated with ITO/AZO is the active sensing region,whereas tapered regions are meant for bringing the incident angle close to the critical angle.The sensitivity of the present fiber optic bio-sensor is evaluated for first two LMRs utilizing both ITO and AZO separately,along with its variation with the taper ratio (TR).For ITO,the maximum sensitivity values are observed to be 18.425 μm RIU-1 (refractive index unit) and 0.825 μm RIU-1,corresponding to the first and second LMRs,respectively,at a TR of 1.6 and for AZO,equivalent values are 0.79 μm RIU-1 and 0.35 μm RIU-1,respectively,at a TR of 2.0.The results illustrate that the first LMR is more sensitive than the second LMR and the ITO-coated probe possesses greater sensitivity than the AZO-coated probe for both LMRs.Similarly,for the fiber optic SPR sensor,the maximum value of sensitivity is 5.6425 μm RIU-1,in the case of gold and 5.0615 μm RIU-1 in the case of silver,at a TR of 1.6.Hence,the result shows that the sensor with the present fiber optic probe design has around a 3-fold enhancement in sensitivity compared with conventional SPR sensors.This study will have applications in many sensing schemes where the requirement of large sensitivity is vital.