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高通量测序技术(high-throughput sequencing),又称为新一代测序技术(next-generation sequencing,NGS),具有高准确性、高通量、高灵敏度和低运行成本等突出优势。随着高通量测序技术的迅猛发展,科研工作者开始越来越多地应用高通量测序技术来解决各种生物学问题。高通量测序技术的发展同样为检验检疫研究带来了新的思路与方法。本文结合近年来所发表的相关文献,对高通量测序技术在病原物鉴定、新病原物发现、环境中病原物种群鉴定、病原-寄主互作、病原流行与传播以及病原耐药性研究方面的应用做了概述,并展望该技术在检验检疫中的应用前景。
High-throughput sequencing, also known as next-generation sequencing (NGS), offers outstanding advantages such as high accuracy, high throughput, high sensitivity, and low running costs. With the rapid development of high-throughput sequencing technologies, scientists are increasingly using high-throughput sequencing technologies to solve a variety of biological problems. The development of high-throughput sequencing technology also brings new ideas and methods for inspection and quarantine research. In this paper, in recent years, published in the relevant literature on high-throughput sequencing technology in the identification of pathogens, the discovery of new pathogens, the identification of pathogenic species in the environment, pathogen - host interaction, the spread of pathogens and pathogenic drug resistance studies The application has been outlined, and prospects of the technology in the application of inspection and quarantine prospects.