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学习和记忆作为大脑的高级功能,其生物学机制十分复杂。而重金属作为污染环境的重要物质,由其中毒引起的以学习记忆损伤为主要表现的认知障碍等相关疾病的发病率在不断增长,形势不容乐观。有研究表明,在由重金属引起的学习记忆受损的过程中,N-甲基-D天冬氨酸受体(N-methyl-D-aspartate receptor,NMDAR)和多巴胺受体(Dopamine receptor,DR)发挥了重要作用。该文就NMDAR和DR在重金属致学习记忆损伤中的研究进展作一综述。
Learning and memory as a high-level function of the brain, the biological mechanism is very complicated. As an important substance that pollutes the environment, the incidence of heavy metals such as cognitive disorders, which are mainly caused by learning and memory impairment, is constantly increasing. Therefore, the situation is not optimistic. Studies have shown that in the process of impaired learning and memory caused by heavy metals, N-methyl-D-aspartate receptor (NMDAR) and dopamine receptor (DR) )It played an important role. This article reviews the progress of NMDAR and DR in learning and memory impairment induced by heavy metals.