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对３０例绒毛膜癌患者及３０例正常妇女进行自发姐妹染色单体互换（ＳＣＥ）及丝裂霉素Ｃ（ＭＭＣ）诱发ＳＣＥ率的研究，分析了绒毛膜癌患者及正常人不同年龄组淋巴细胞ＳＣＥ率的变化。结果表明：①不同年龄组自发及ＭＭＣ诱发ＳＣＥ率无明显差异，ＳＣＥ率的变化不受年龄因素的影响。②绒毛膜癌患者自发及诱发ＳＣＥ率明显增高，自发ＳＣＥ率为（７．２８±０．３４）；诱发ＳＣＥ率为（１３．９６±０．２６），ＳＣＥ未回复率是正常对照组的２．０倍。ＳＣＥ未回复率越高，ＤＮＡ损伤后修复能力越差。
To investigate the SCE rate induced by spontaneous sister chromatid exchange (SCE) and mitomycin C (MMC) in 30 patients with choriocarcinoma and 30 normal women, we analyzed the correlation between SCE rate in choriocarcinoma patients and normal subjects Change of lymphocyte SCE rate. The results showed that: ① spontaneous and MMC-induced SCE rates in different age groups were not significantly different, SCE rate changes were not affected by age factors. ② The spontaneous and induced rate of SCE in patients with choriocarcinoma was significantly higher than that in normal control group (spontaneous SCE rate was (7.28 ± 0.34), SCE rate was (13.96 ± 0.26), SCE unresponsiveness rate was 2.0 times. The higher the non-response rate of SCE, the worse the repair ability after DNA damage.