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目的 了解结核纯蛋白衍化物（PPD）结果与婴幼儿哮喘及细胞免疫的关系。方法 将接种卡介苗后的婴幼儿100例按有无哮喘分为实验组及对照组,检测PPD皮试及外周血T细胞亚群CD3+、CD4+、CD8+水平。结果 实验组PPD皮试阳性6例（6/50）,阳性率12％;对照组阳性30例（30/50）,阳性率60％,实验组PPD阳性率较对照组明显降低（x2=8.92 P<0.01）。实验组CD3+（69.05±5.55）％、CD4+（45.67±6.03）％、CD8+（24.32±3.06）％、CD4+/CD8+（1.66±0.36）％与对照组[分别为（67.33±5.96）％、（42.95±7.21）％、（22.37±3.97）％、（1.47±0.28）％]相比均增高,t分别为2.54、2.45、2.80、2.98,P均<0.05,差异有显著性。结论 PPD结果与哮喘及免疫状态有密切关系。
Objective To understand the relationship between tuberculosis pure protein derivative (PPD) and infant asthma and cellular immunity. Methods 100 cases of infants after BCG vaccination were divided into experimental group and control group with or without asthma. The level of CD3 +, CD4 + and CD8 + of T cell subsets in PPD skin test and peripheral blood were detected. Results The positive rate of PPD in experimental group was 6% (6/50), the positive rate was 12%. The positive rate of control group was 30% (30/50), the positive rate was 60%. The positive rate of PPD in experimental group was significantly lower than that in control group (x2 = 8.92 P <0.01). Compared with the control group [(67.33 ± 5.96)% and (42.95)%, the positive rate of CD3 + in the experimental group was significantly higher than that in the control group (69.35 ± 5.55%, CD4 + 45.67 ± 6.03%, CD8 + 24.32 ± 3.06%, CD4 + / CD8 + ± 7.21)%, (22.37 ± 3.97)%, (1.47 ± 0.28)%], respectively, t = 2.54,2.45,2.80,2.98, P <0.05, the difference was significant. Conclusions PPD results are closely related to asthma and immune status.