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患者,女,17岁,体重49kg。因“右腿红肿疼痛”于1999年1月25日入院。经确诊,为“右胫骨上端骨肉瘤”。既往无药物不良反应史。室验室检查:白细胞 4.2 ×10~9/L,红细胞 4.17×10~(12)/L,血小板159×10~9/L.,ALT 9U/L,AST 22U/L,肝肾功能正常,遂决定执行化疗方案。经水化碱化后,于1999年2月1日给予患者静滴甲氨蝶呤12g,滴注时间4h,并于滴注完毕后6h给予患者肌肉注射甲酸四氢叶酸钙15mp进行解救,每6hi次,共12次。二月6日,患者唇及口腔有少许溃
Patient, female, 17 years old, weighing 49kg. Because of “right leg swelling pain” January 25, 1999 admission. After diagnosis, “right tibial osteosarcoma.” Past history of adverse drug reactions. Laboratory tests showed that white blood cells were 4.2 × 10 9 / L, erythrocytes 4.17 × 10-12 / L, platelets 159 × 10-9 / L. ALT 9U / L, AST 22U / L, liver and kidney function was normal, Then decided to implement the chemotherapy regimen. After hydration and alkalization, on February 1, 1999 patients given methotrexate intravenous infusion of 12g, infusion time of 4h and 6h after infusion of intramuscular injection of calcium formate tetrahydrofolate 15mp for rescue, each 6hi times, a total of 12 times. February 6, the patient’s lips and mouth a little ulceration